i find that a little caffeine will get the darvocets working pretty quick. i used to take 1 or 2 excedrin migraine pills with them to get them working, 3 pills should work that way, but keep in mind that is a lot of tylenol to take, you're better off getting a caffeine pill or drinking a mountain dew...don't do energy drinks though, all that other stuff in them besides caffeine can react with the darvocet and make you sick