St. Johns wort worked great for me and my depression but you do have to be careful because it is known to interact with several prescription drugs. I took the st johns wort and magnisium and it was a miracle combination for me. Kava Kava root is supposed to be another good one for depression and anxiety but it has been said that it can have some side effects which may include liver toxicity and you should consult with your doctor before starting either. And with all supplements buy from a trust company because they are not regulated like most think.