my girlfriend suffers from chronic depression. all medication shes tried has done nothing for her. She even tried (not thought but tried) suicide previously while on them. Pot is the one and only thing that keeps her level and happy most of the time. No other drugs what so ever have ever helped her. she constantly finds herself unhappy for no reason whatsoever. I've never heard it not helping depression but it makes sense. Unfortunately almost every medication for depression can have an opposite effect. Take lexapro for example, one of the listed side effects is you may become suicidal. Even if you weren't suicidal before, only mildly depressed, after taking it you may try to commit suicide. Depression is an odd thing thats very very very hard to cure, unless you believe Tom Cruise of course, then it's just all in your head.