Every grower will want to clone at some point. Either you have some crazy plant you want to keep forever, or you just want to cut some time off your grow cycle, this is how to do it without the expense (and frustration when it doesn't work) of a commercial cloning machine.

Materials:
One package of composted tree bark cloning plugs- I use 'Rapid Rooters'. They are very good and have fungicidal properties. You want that, trust me!
One bottle of Dip-N-Grow concentrate- there are lots of cloning solutions, powders, and gels on the market. Don't waste your money, this one is by FAR the best, and it is cheap. Follow the mixing instructions for softwood cuttings. I think the ratio is 1:20.
An exacto knife with a fresh blade
A clean cutting surface- a pad of sticky-notes is GREAT, and I also like to use beer mats, you know, those little bar coasters?
A small pair of sharp scissors
A propagation tray and dome, either new, or if used, wash out and then sterilize with Scrubbing Bubbles foaming bathroom cleanser. Hit every surface. Allow to sit 15 minutes. Rinse it off. Trust me, that stuff was like MADE for growrooms.
Some nursery 6-packs that can hold your rapidrooters upright. Run them through the dishwasher before use, or clean as for the tray and dome
Lighting- I use a single CFL hung right over my dome. You can use your shop lights. Don't use a MH! It's too bright
A spray bottle. The ones that hair polishing products come in, that give the FINEST mist, are ideal. Your girlfriend will be pissed if you dump out the contents though, so ask first.
In the winter, if your house is wicked cold, you also need a seedling heat mat, but if you are above 68 degrees, you are fine- the light gives off a bit of heat too.

Prep your mother. She wants no Nitrogen for the week before taking cuttings, so feed her with a bloom fert and superthrive. About a half hour before use, water her well with plain water.

Pick a shoot that has a growing tip, preferably the most vigorous one on the plant, plus a couple small fans leaves right at the growing tip, and then further down the stem, another node whcih you will be stripping off in a moment.

Make a clean cut with your scissors about an inch below the lower node. Now, working quickly, lay the cutting on your sticky note pad or whatever and cleanly slice off the lowest leaf flush with the stem. Just below that, make a cut at a 45 degree angle and IMMEDIATELY dunk it into the dip n grow. Leave it there for about 10 seconds.
While the cutting is in the dip n grow, take your rapidrooter and slice another hole in the top. The one from the factory is too big for cannabis. You want no air around the cut stem, and good contact with the medium. Just plunge your exacto blade in there. Now gently push the base of the cutting in there. The stripped node must be below the plug surface.
Take your scissors and cut all remaining leaves down to only 1 inch long. You may write the name of the plant right on a leaf with a black sharpie. I use a code 3 characters long to identify strain and plant ID.
Put it in the 6 pack to stand upright, place under the dome, put the dome under the light, and make as many more as you want.
Don't crowd your plants. Air flow now, like at all other life stages, is important.
When you are finished making cuttings, fill your rinsed spray bottle with tap water and thoroughly spray the inside of the clear dome. I don't like to spray the cuttings directly, as water sitting on them can encourage rot.
Keep an eye on them and if they do wilt, mist them.
Also do not let the plugs dry out!!! They should not be sopping wet, but give them a few drops of water every so often.
In about 2 weeks they will be showing upwards growth and be ready to transplant. Treat them as you would a seedling being transplanted for the first time, but a light mist with wilt-pruf or even neem oil helps prevent any shock from going into a drier environment.

Quote Originally Posted by qdavid
I've tried to find it but haven't been able to yet, but can a clone be taken from a grown plant that was originally a clone itself? I wonder if the potency of the finished product would be diminished due to the genetic filtering you'd be inadvertently doing as kind of an unwanted side effect?
Yes, you can clone down indefinitely- the OG Kush lines' original germination date is over 20 years ago. Some subtle changes ( I guess what you are referring to as genetic filtering- actually a simple failure in RNA repair at the cut site) HAVE occurred over this time, but the plant is still potent and vigorous. Always take care not to stress your clones or mothers, and you will continue to see success for a long time to come.


Care of new rooted clones:
Once your cuttings have been rooted and vegging solidly for at least a week, take these steps to ensure that they are strong enough to survive outside the controlled environment in which you've been keeping them.

Their basic needs are pretty simple. Start them on 1/4 strength grow nutes, given in the water or as a foliar feed. For lighting, they can go under a pair of 40w, 4-foot, T12 'cool white' flourescent shop lights, or any flourescent fixture that gives you enough light for the number of plants you have. You may continue vegging them under these lights until it is clear that they are well-established in their pots, and then put them under your HIDs, or outdoors. If they go outdoors, keep them out of direct sunlight for the first couple days, and protect them against rabbits with a chicken wire cage.
They are also ready to be topped, trained, or flowered as a single-cola plant. If you pinch the tops, allow at least 2-3 weeks for recovery before initiating flower. Outdoors, avoid topping after the first week in July. Yield can suffer.