Mine's got stories, and even what would be considered an in-between-level den/living area, and frankly, it's a hassle. Going up and down stairs. Vacuuming them. Chasing little animals around. Hauling laundry up and down. Trying to get others in the upper distant end of the house to hear you. I'd much prefer a one-story house, and my next one is going to be that way.

It's been my experience that multi-story homes always sound better than they live. The one big advantage is that most of the bedrooms are upstairs, which means the downstairs stays more clean and presentable.