It's asolutley safe, as long as you don't plug the ballast in.

The hps 400 bulb requires a much higher amperage at the startup surge than the 250.

Depending on the bulb manufacture, the 250 will either cook as soon as you fire it, or cook within the first week.

Also, transformer will not match load, which will cook it down mighty quick.

Bulb MUST match ballast.