BE VERY CAREFUL WHEN TAKING ANTI-DEPRESSANTS AND SMOKING WEED!! Search online for marijuana and _______ (your antidepressant) before doing it again. I was on amitriptyline for headaches (about 1/4 of normal antidepressant dosage) and it apparently speeds up ur heart-rate, and so does weed. I smoked really good weed the first time I had smoked while taking the pills, and thought my heart was gonna jump out of my chest. I asked my friend a bunch of times if the weed was laced, I felt so weird. I later read online that someone had died from the combo, due to heart problems. Lesson - always research first.