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Matt the Funk Reviewed by Matt the Funk on . Scientific reasoning Ten years ago, the popular belief was that caffeine didn't act on any specific neurotransmitter or receptor site. The popular belief was that caffeine acted by increasing the permeability of calcium on the intracellular level. Fortunately science is not set in stone, so when new evidence presented itself the popular belief changed. It is now believed that caffeine acts mainly through its structural similarity to adenosine, but in another ten years that could go out the window also. This is Rating: 5