I used it for several months about 6 years ago and had that same experience, Yankeesgirl--it didn't seem to be as effective after several months as it did in the beginning. That caused me to wonder whether, in me, the initial mood boost might have simply been a placebo effect.

I have a new neurologist I'm about to see about some problems I'm having, several of which are making me feel lower than I normally do, and I'm going to ask him what he thinks about 5-HTP. I also want to know if it interacts with other meds in any way.