100% female plants, seedlings treated wColchicine

The method:


plant your seeds, sprout as usual

half fill an empty tic tac box with water

put in a single 0.6mg tablet of Colchicine

let it sit until the tablet disolves

as seed coats drop, start treatments

use an eyedropper to place a BB size drop

give a drop in the am, and a drop in the pm

continue treatment for five days

white deposit on the treated area is normal


That's it. From there just grow and flower the plants.

Sorry to be so terse, but I really need to be careful
and this information had to be shared.

I'm not smoking ANYTHING treated that stuff... but that's just me.
http://www.sciencelab.com/xMSDS-Colchicine-9923531

Colchicine is used to treat gout. If you have gout, you take
1 pill per hour until the pain subsides. Usually 3-4 pills
are ingested to bring relief.
A single 0.6 tablet disolved in water as described above can
treat around 30 seedlings that then (hopefully) grow
50 to 100 times larger. So the potential residue in a crop of
30 grown plants would be 0.6mg max. This is tiny compared to
the therapeutic dose a gout sufferer uses. Homeopatic for
all practical purposes.

sounds like they ARE out to get him.........:D Sorry but I find the paranoia amusing.

Just because I'm paranoid, doesn't mean they're not out to get me! Seriously, got burned by LO once. Never again.

I harvested my last plant (11th). Had 1 hermaphrodite, the
other 10 were all females. Very nice since I had early losses
due to rodents. I developed a few sprays to keep deer and
mice/rats away.
1. Grow opium poppies and brew the dry plants into a very bitter tea.

2. place a cheap cigar in a bottle of water for a week.

Both teas were very effective at discouraging pests.

And I had a bout of the gout, had to use 3 Colchicine pills
over a 3 hour period. They didn't kill me, and cured my
gout. I must drink LESS and smoke MORE!

I recognize this as an ancient thread, but I have been fascinated with this for a long while now.

"Colchicine inhibits chromosome segregation to daughter cells and cell wall formation, resulting in larger than average daughter cells with multiple chromosome sets. The studies of H. E. Warmke et al. (1942-1944) seem to indicate that colchicine raised drug levels in Cannabis." -end quote

He germinated around 1000 seeds in a good bit of colchicine laced water and found that only a select few would sprout and grow... the other seeds became useless.

The seeds that sprouted and grew came to be known as polyploids... they have more than two sets of chromosomes. Theoretically you could make a blueberry-kush-skunk-haze plant if you could run the genetic line properly - that is my goal in the long run. In the end of the experiment, by the way, the plants were considered to be more potent than would have been if not treated.

The first generation of plants, though, were known to be toxic, but the second generation (not clones.... seeds) were okay to grow and consume. The difficulty of successfully growing multiple strains and generations of polyploid plants has kept it from becoming more mainstream.

Just my:twocents:

Aussie Bastard Cannabis Redux | Cannabis Culture Magazine
Cool stuff, huh?

Quote:

---

Originally Posted by infogift1967

I developed a few sprays to keep deer and
mice/rats away.
1. Grow opium poppies and brew the dry plants into a very bitter tea.

---

And we haven't heard from him since this revelation. I wonder why...?

If you wish to change the genetics, go for it. But I have a hard time unederstanding what the end-game is. The risk of personal injury is enough to recommend caution for those you share the frankenbuds with. And even worse, you risk genetic degredation of the cannabis strain itself.

Again...to what end? Real cannabis not medicating you properly? (the potency theory is bullshit, btw)

Just keep those frankenseeds off the market unless you offer full disclosure, as your strains will be tainted and possibly unstable.

Just an update, I'm alive and well. And how does my garden grow? With silver bells and cockle shells and pretty MAIDS all in a row. :) Had a few hermies, but again about 90% were female again this year.

My theory is the colchicine applied to newly sprouted seedlings stress them in a way that makes them switch on the genes to develop into female adults.


Since colchicine is an alkaloid, it degrades with exposure
to sunlight and weather. Only a tiny fraction of a single
pill is actually applied to each seedling. The chances of any
residual colchicine in the harvested material is almost nil.

(your mileage may vary)

Almost nil...? Sorry, not good enough.

Just because other sites tout it's effectiveness and claims of it being a 'residual' ammount of poison, it's a poison. How much of that poison will your body store, before reaching a toxic and irreversable level? And about smoking the vapors from that poison...does it make the compound safer or more toxic?

Being as how this is a medical cannabis site, and there are many folks here that even though it's a small ammount of poison, it could and would interract with some meds or medical conditions, and it's not worth the risk of injury or worse to a loved-one.

There are much safer alternatives for femming seeds. Light poisoning or aspirin treatments, for instance.

Colchicine is a drug. It, like any other drug or substance can be toxic depending on the dose. Even tap water is toxic if you ingest enough at one time.

Since a gout patient takes three or 4 pills (0.6mg ) the theraputic dose is 1.8 to 2.4 mg in a single day. This is direct oral ingestion.

Contrast that with a single pill (0.6mg), a fraction of which is applied to several seedlings and then exposed to intense light for some months, which completely degrades the original alkaloid.

But to be fair, the most realistic hazard would be to carelessly handle
the colchicine when applying it to the seedlings. You wouldn't want to wet your fingers with it, and wipe your eyes for example. But then I wouldn't want to get fertilizer or beer in my eyes. It all comes down to common sense.

Are you by chance an MD? If not, I would like to request you stop giving blanket medical evaluations and drug safety advise. For some, it quite possibly could be, at the very least...harmful. I understand the dilutions argument, but you still have no clue as the safety for those on a regimented drug schedule for treatments of shitloads of diseases or conditions. "Because the guy's at the other site said it was ok" is not a valid argument.

Colchicine (Colchicine) Drug Information: Uses, Side Effects, Drug Interactions and Warnings at RxList

"Adverse reactions in decreasing order of severity are: bone marrow depression, with aplastic anemia, with agranulocytosis or with thrombocytopenia may occur in patients receiving long-term therapy. Peripheral neuritis, purpura, myopathy, loss of hair, and reversible azoospermia have also been reported.

Vomiting, diarrhea, and nausea may occur with colchicine therapy, especially when maximal doses are necessary for a therapeutic effect. To avoid more serious toxicity, the drug should be discontinued when these symptoms appear, regardless of whether or not joint pain has been relieved.

Dermatoses have been reported. Hypersensitivity reactions may occur infrequently."

Drug Interactions:
Colchicine is inhibited by acidifying agents. The action of colchicine is potentiated by alkalinizing agents.

Colchicine may increase sensitivity to the CNS* depressants.

Response to sympathomimetic agents' may be enhanced by colchicine.


*CNS stands for central nervous system.

Doubtful 95% (random number) of us would have a problem. But you are willing to risk it for the remainder of the group...?

I would like to take this opportunity to extend this warning to products like gibberellic acid, hormones, steroids. Know what you're using, as it may affect you adversely.

Being a woman, anything that affects your chromosones at birth (Or germination ;) ) makes me think about flipper babies.

I dont want flipper babies.

this may just be me, but i think a fact has been overlooked. Most "medical marijuana" users take other prescription drugs. I could see this drug interacting with other drugs they are taking causing serious harm

I believe someone mentioned the key thing. You have to grow the seeds that were a result of the plants being treated with the colchicine and get seeds from those plants but you CANNOT smoke those plants from the first generation of colchicine treated seeds. Just second and subsequent generations. Also as mentioned they will then be polyploid but I have not heard of colchicine causing the seeds to be female. If the seeds result in all female plants you would have to get another male somewhere to create the second and subsequent generations that you can smoke.

Has anyone heard of any negative effects from the second generation seeds. Any information on whether there is any colchocine in the subsequent generations.

Colchicine treated plants are sterile and must be cloned.

a reminder: Colchicine is a hazardous, dangerous, substance ... DO NOT USE COLCHICINE ! ... there are many ways to grow superior plants, with no risk, learn them, use them ... this whole 'feminized' fad blows, anyway :wtf: ... grow out your plants, from 'regular' seeds, select your best females, and clone them :thumbsup:... :smokin:

... grow out your plants, from 'regular' seeds, select your best females, and clone them

True that. The quality is soooo good and available now adays that messing with marginal and difficult chemicals is a very bad idea.:smokin:

interesting,infogift1967

Three or four colchicine? I WISH! I've had multiple gout flare-ups - the kind where the sheet catching your toe nail in the night wakes you in a cold sweat screaming. My doc's always told me to take two at first, then one every hour until I feel sick to my stomach. The bottle even says "until you vomit.."

On average, I take them for 15 hours and drink as much water as I can stand. Seventeen pills by .6 mg each runs to be 10.2 mg, and I've had to take this dose at least 10 times in the past three years. I imagine my body (6', 165 lbs) could easily withstand 20 mg in a day.

I understand the quality of genetics has improved vastly, but there's always room for science! Right?!

Besides, colchicine can't replicate! The smallest dose of it in the soil wouldn't metabolize through the fruiting phase, anyway.

Keep up the great work y'all! Wish I was there with ya!