I spoke with an Organic Chemistry major. He smokes weed, and is AWESOME. Read this.

He says that the cigarette company R.J. Reynolds already has a genetically engineered "super pot" in a greenhouse/warehouse. He says they are waiting to release it to the public once marijuana becomes legalized. This makes me think that the myth surrounding G-13 might not be such a myth. He says he and his friend planned to "break in", just to see what this super pot was like, but they said security was so tight that it was virtually impossible.

He told me cannabinol was an alcohol, and part of the high comes from dehydration from the brain. The reason eaten weed has a different high than smoked weed is because it is processed through the liver, which in turn changes the high and length of time it lasts.

He informed me that THC was such a small compound, consisting of carbon, nitrogen, oxygen and hydrogen (I think, I can't remember exactly, but anyone who wants to break apart the name with IUPAC can figure it out) that easily fits through the membrane surrounding the brain, a sort of blood membrane. The cannabinoids go directly into the brain, passing through the membrane that blocks many other chemicals out.

He also started telling me that the "cannibinoid receptors" are not actually "designed" for cannabinoids, per se, but they are reactive to many other chemicals also. The way the cannabinoids react to the receptors is what produces the high.

He is writing a paper on cancer (forgot what he was writing, nothing completely new, though, just reinterpreted research) which states that cancer cells are actually DESTROYED by THC, not just inhibited from growth. He also says though, that it kills many other cells, too.

He notes that the extreme heat from the cannabis smoke is the only thing that really damages the body. The THC is entirely safe (as all of you know). In other words, vaporizing is entirely healthy.

Smoking out of a bong, he says, filters the smoke, but not like most people believe. It does not filter the tar or chemicals, but mostly just the "scoobs" and other tangible smoke. The tar and other chemicals are still there.

He says that cancer researchers have BLOCKS, yes SOLID BLOCKS about a foot in both length, height, and width of SOLID THC that they use for research. You must have a special permit to access these blocks.

We talked alot more, I can't really recall everything, but this just gives you an idea. He was awesome. :thumbsup:

Wow.. blocks of THC... ridiculous. Is there a way to synthesize THC? There's gotta be somehow...

But anyhow, that's pretty awesome about the superpot haha. I really should buy a vape, but I dont have the cashmoneys now. Vapes are so much healthier *sigh*

Herb likely is not getting legalized anytime soon. lawmakers don't want everyone stoned, they might see the truth about shit that goes on in this country...

the cigarette company making pot rumors have been around a while... "Marlboro Marijuanas"

delta 9 thc is converted by the liver into delta 11, a much more psychoactive form...

solid THC blocks? "and rocking-horse people eating marshmellow pies" i wanna trip whatever you guys were!

:)

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Originally Posted by melodious fellow

Herb likely is not getting legalized anytime soon. lawmakers don't want everyone stoned, they might see the truth about shit that goes on in this country...

the cigarette company making pot rumors have been around a while... "Marlboro Marijuanas"

delta 9 thc is converted by the liver into delta 11, a much more psychoactive form...

solid THC blocks? "and rocking-horse people eating marshmellow pies" i wanna trip whatever you guys were!

:)

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I mean, he came and visited our Honors Organic class, he goes to Wake Forest and is graduating with honors in Organic Chem, specifically studying cannabis. I really assume he knows what he's talking about. He is fuckin' smart.

most cannaboids are metabolized in the liver, (but some are stored in fat too) it doesnt matter if you smoke it, vape it, eat it, use a transdermal patch, intravenous injection, take it sublingually, or rectally. Delta-9-THC is metabolized to 11-hydroxy-delta-9-THC through all of these methods of administration. 11-hydroxy is then metabolized into 9-carboxy-THC, which is a metabolite; this is what drug tests are designed to look for.

As far as synthetic thc or cannaboids, there are a whole wack of them. One of them is HU-210 (1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol) which mimics natural thc, but is 100-800x more potent. HU-210 is a full agonost, for the cb1 receptor, where as thc isnt, meaning that every single of thc's effects would be magnified by 100-800 times, making fatal overdoses possible! :(

Yay science.

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Originally Posted by Zonyc

most cannaboids are metabolized in the liver, (but some are stored in fat too) it doesnt matter if you smoke it, vape it, eat it, use a transdermal patch, intravenous injection, take it sublingually, or rectally. Delta-9-THC is metabolized to 11-hydroxy-delta-9-THC through all of these methods of administration. 11-hydroxy is then metabolized into 9-carboxy-THC, which is a metabolite; this is what drug tests are designed to look for.

As far as synthetic thc or cannaboids, there are a whole wack of them. One of them is HU-210 (1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol) which mimics natural thc, but is 100-800x more potent. HU-210 is a full agonost, for the cb1 receptor, where as thc isnt, meaning that every single of thc's effects would be magnified by 100-800 times, making fatal overdoses possible! :(

Yay science.

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Awesome post.

What I meant was that instead of some of the cannabinoids being processed through the liver and some going directly through the brain via bronchioles and capillaries in the lungs, all of the cannabinoids are processed by the liver when eaten.

And although fatal overdoses may seem possible, the amount of marijuana it takes to kill a human has been tried, and tried, and tried again, but still has not determined a significant value. Scientists usually call this the "half-value" (or something like this), where they determine half of the dose of a chemical it takes to produce a lethal effect). I hear the rate of consumption of the highest grade marijuana has is 1.5g every second for fifteen minutes. Which makes me think that even with an ultra-high dose of a synthetic THC compound, it still would not produce a fatal effect, simply because the receptors will just "shut off" if they are overstimulated.

Not saying your wrong, though. I just believe that even by maginification of the high by 800x still would not produce a fatal effect. I'm no scientist though.

brand name on the market "Marinol" you can find it in most pharmacies only with a prescription.

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Originally Posted by TPot

Awesome post.

What I meant was that instead of some of the cannabinoids being processed through the liver and some going directly through the brain via bronchioles and capillaries in the lungs, all of the cannabinoids are processed by the liver when eaten.

And although fatal overdoses may seem possible, the amount of marijuana it takes to kill a human has been tried, and tried, and tried again, but it has not hapenned yet.

Not saying your wrong, though. I just believe that even by maginification of the high by 800x still would not produce a fatal effect. I'm no scientist though.

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Nothing goes right to the brain without being metabolized, your body doesnt work that way.

While ODing on marijuana isnt humanly possible ( 50-86g in one sitting for a 150lb person), it does have a sedetive effect, and as HU-210 is a full agonist, this sedetive effect would prove to be fatal at just a fraction of those doses.

Well you can pretty much bet your bottom dollar that the cigarette companies would take full and utter control of the marijuana industry if it became legal, super weed or not. Most have probally already thought of packaging and other such ventures.

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Originally Posted by Zonyc

Nothing goes right to the brain without being metabolized, your body doesnt work that way.

While ODing on marijuana isnt humanly possible ( 50-86g in one sitting for a 150lb person), it does have a sedetive effect, and as HU-210 is a full agonist, this sedetive effect would prove to be fatal at just a fraction of those doses.

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Oh cool dude, I didn't know that.

Are you a chemist? You seem to know an awful lot.

I'm an undergrad in a science program, goin for a chem major though. Wikipedia is an awesome resource for learning how this lovely stuff effects us too.

This thread is win.

I enjoyed the reason of that info.

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Originally Posted by TPot

Awesome post.

Scientists usually call this the "half-value" (or something like this), where they determine half of the dose of a chemical it takes to produce a lethal effect). I hear the rate of consumption of the highest grade marijuana has is 1.5g every second for fifteen minutes.

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What you're referring to is the LD-50, or lethal dose in 50% of the sample (not the half of the lethal dose). I don't think the value has been calculated for smoked cannabis, but for eaten cannabis at 5% THC (this is pretty low grade stuff), it's around 2-5 lbs for a 150 lb person. So, virtually impossible.

I don't trust the cigarette companies for anything and especially I don't want no "genetically engineered" shit. I'll take what nature gives me, thank-you. I never believed we have these specific cannibanoid receptors specifically for just cannibas. That makes no sense. True scientific research develops hypothesis based on results, but very often research is based on results to prove a hypothesis. Therefore I'm skeptical of any conclusions such as the small molecules getting into the brain. What? I suggest you take any so called "experts" with a grain of salt. Anybody and everybody can try to contribute to Wikipedia. They try to filter bullshit but that's kind of hard to do with so much floating around. Flame-on batman.

Do me a big favor, will ya? Get him over to a computer, and click the link in my sig. Let him read it. It might inspire some interesting results later in his career. :D - Granny:hippy:

PS- It is also on a purely medical site, TreatingYourself.com, if you don't want to expose him to Cannabis.com just yet.

My birthday gift to you.... - TreatingYourself.COM Online Community

Okay Crow. Chill baby. You're right. We both know it. So do most people. I was gonna come back here to say, "Sorry. Too much coffee. I don't really give a shit." But she's right....."I remember my undergrad, know everything about everything days"....Snaps out of dream.

This thread rocks, thanks to Crow's links i actually found something interesting to read for the next couple of days, very interesting i might just start writing letters.

Very interesting. Very interesting, indeed.

And Crow. I'm taking a very detailed look at your journal. It's amazing. Thank you.

good thread... i want to learn sum of that shyt Zonyc knows about.. makes me want to explore cannabis even more... maybe once I'm a master at growing i'll look into its effect(s) on the body

wake forest eh? small world. Very interesting stuff though.