Sleeping Pills

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Originally Posted by IanCurtisWishlist

fuck antihistamines. if you take enough you might have a really weird trip.. keep it au natural and take 1 melatonin before bed and wake up feeling like you got some sleep. when i take antihistamines to sleep i wake up feeling like i took a handful of fucking quaaludes or something.

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I would take melatonin if it were eaier to find low dosages, - newer research has shown that less is better. .25 mg is a good amount, but most of the brands are much higher.

As for using an antihisamine for sleeping, I don't think that you're supposed to take enough to "have a really weird trip". All I take is one pill, Diphenhydramine HCI 25 mg., and that's enough to go to sleep. I haven't had any quaaludes in decades, but I remember that they were MUCH stronger than this OTC allergy medicine - at least for me.

Hey, Moeburn. I'm not so old a dog I can't learn some new tricks. And I'd love to know your source on that quote about Bendryl leading to the invention of fluoxetine. I want to show it to our pharmacology professor and find out why that's not in our med school pharmacology info. If I can show him the source, I can ask him about it. So if you're not too busy sticking your tongue out at me, please share that with me. And be prepared to hear what I expect will be his response: that just because one chemical affected serotonin reuptake and led to the discovery of another different chemical doesn't mean they're the same drug or in the same category at all. Just a hunch. Another hunch tells me that you're probably firmly entrenched in your belief that they are identical chemicals, which is fine, since I rather doubt you'll ever be prescribing them to others.

Seriously, I'd like your source of that quote. Thanks!

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Originally Posted by birdgirl73

Hey, Moeburn. I'm not so old a dog I can't learn some new tricks. And I'd love to know your source on that quote about Bendryl leading to the invention of fluoxetine. I want to show it to our pharmacology professor and find out why that's not in our med school pharmacology info. If I can show him the source, I can ask him about it. So if you're not too busy sticking your tongue out at me, please share that with me. And be prepared to hear what I expect will be his response: that just because one chemical affected serotonin reuptake and led to the discovery of another different chemical doesn't mean they're the same drug or in the same category at all. Just a hunch. Another hunch tells me that you're probably firmly entrenched in your belief that they are identical chemicals, which is fine, since I rather doubt you'll ever be prescribing them to others.

Seriously, I'd like your source of that quote. Thanks!

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http://www.psychosomaticmedicine.org.../full/61/5/591
http://en.wikipedia.org/wiki/Diphenhydramine

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With the ethylamine core, it also has atropine-like effects to block the muscarinic effects of acetylcholine (mAChR antagonist) and is a serotonin reuptake inhibitor. The former actions are well known. The latter may surprise you, but that is a tale later in the history of the development of selective serotonin reuptake inhibitors (SSRI).

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You're right though, diphenhydramine is not strong enough to produce SSRI effects on its own. The association of it to SSRI's still bugs me though, because I have bad personal and family history with that class of drugs.

Substituted Methoxyethylamine (Diphenhydramine, Benadryl®)
compared beside
Substituted Phenoxyphenylpropylamine (Fluoxetine, Prozac®)

http://www.psychosomaticmedicine.org.../61/5/591/FIG7

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Originally Posted by moeburn

http://www.psychosomaticmedicine.org.../full/61/5/591
http://en.wikipedia.org/wiki/Diphenhydramine
You're right though, diphenhydramine is not strong enough to produce SSRI effects on its own. The association of it to SSRI's still bugs me though, because I have bad personal and family history with that class of drugs.

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Thanks, Moeburn! Glad to have those links.

Yep, I just really hated the side-effects I experienced when I tried Effexor some years ago, and I had similar side effects with Paxil. Since then, I've avoided those drugs completely. I generally have classic wintertime depression (seasonal affective disorder) when the days get short and there's not enough light. But these days I use full-spectrum light bulbs and daily exercise. I just don't ever want to put up with that yucky, subdued, flattened feeling I had on SSRIs again. It was miserable, and then to top that off, they're hard to get off of. I know a good many people for whom they've worked well and don't think everyone should rule them out, but for me, they're not the answer. Plenty of light and exercise seem to help me get through the winter months just fine--and no side-effects.

Take care, Moeburn. And thanks again for the links.

Well, I admit I didnt read through every post here... But sleeping pills are my 'speciality'. OTC stuff is all shit... Whether it is Tylenol PM, allergy med, or whatever, if it is OTC it is just an antihistamine (diphenhydramine hydrochloride)... Ok to-a-point.

I prefer benzos... Xanax is my fav but I also buy Versed online (most powerful benzo that is usually used as an IV sedative before surgery but can be bought in pill form). Anti-psychotics can also do the trick but they can be pricey and a lot of them react to a lot of other drugs (dont want to mix em with the wrong shit).

The thing to be aware of with any med is tolerance. That is why I alternate between Xanax (benzo), Versed (benzo), Seroquel (Anti-psychotic), and diphenhydramine hydrochloride based products OTC. Add a little ganja and alcohol and you're in for a great night sleep :)

I am right now on my 7th day on taking my tollerance break from smoking everyday for 2 years and I too had sleeping problems. I went to bed it would take me a hour or longer to fall asleep where as before when I smoked I would fall asleep within mins. I would take a vitamin called Valerian Root which is a natural sleep pills and melatonin with it and they worked great.. I only used it a couple times cause I wanted my system to naturally get back into the habit during this break and I would avoid the sleeping pills just cause they can be worse then the cannabis when you stop using them.

I would exerise everyday, sweat ALOT so you get rid of the thc much faster and you sleep easier overall.