Weed and Pills/Cigarettes

This may be what leads to nervous reactions after smoking Herb.

In my signature, it shows that Marijuana promotes Melatonin production 4,000%.

Quote:

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Originally Posted by WIKIPEDIA ENCYCLOPEDIA BRITTANICA

Melatonin is practically nontoxic and exhibits almost no toxic side effects, except for the occurrence of somnolence in most of the population at higher doses. Exogenous melatonin normally does not affect the endogenous melatonin profile in the short or medium-term. However, melatonin taken in combination with monoamine oxidase inhibitors (MAOIs) can lead to overdose because MAOIs inhibit the breakdown of melatonin by the body. http://encyclopedia.thefreedictionary.com/melatonin
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Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. In the past, they were prescribed for those resistant to tricyclic antidepressant therapy, but newer MAOIs are now sometimes used as first-line therapy.

Monoamine oxidase inhibitors include:

* Isocarboxazid (Marplan)
* Moclobemide (Aurorix, Manerix, Moclodura®)
* Phenelzine (Nardil)
* Tranylcypromine (Parnate)
* Levo-deprenyl (Selegiline, Eldepryl)
* Harmala (present in Harmal, Banisteriopsis caapi, and tobacco; also acts as a serotonin antagonist and CNS stimulant).

There are two isoforms, MAO-A and MAO-B.

Long-term smokers usually have only 40-60% of normal MAO-B activity. http://encyclopedia.thefreedictionar...dase+inhibitor

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I don't think anyone knows what a Melatonin overdose can do, but any drug that blocks monoamine oxidase, including tobacco, won't breakdown the exogenous Melatonin like the brain normally would. That would send levels soaring, in some cases, to a greater extent than those at puberty.

And this pitiful adult-nation is afraid of Marijuana because it makes them "stupid". If only they understood the harm the rest of the World does. :(

can you dumb it down for me a bit lol, I dont understand like any of that hahaha

yea me either...

is it too much Melatonin in the herb that can give you nervous reactions or is it when you mix weed with pills?

fuck! i dont even know what melatonin is...

There are a shit load of things you are supposed to avoid with MAOI's

Quote:

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Originally Posted by 3rdEyeVision

can you dumb it down for me a bit lol, I dont understand like any of that hahaha

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Okay...

Melatonin is a chemical created by your brain which affords protection of your immune system, as well as many other things.

Even cigarettes cause negative reactions when taken in conjunction with Herb.

Melatonin influences your natural cycles. When other things have messed with your melatonin levels, your whole life, the boost from Herb would shock your system, if you're not used to it.

It's just another aspect of Herb, melatonin is.