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I'm curious as to how the body processes shrooms and how a trip occurs in the physical sense inside your body. Are there psilocybin receptors in the brain? Is the trip a chemical reaction in your brain trying to compensate for the psilocybin in your body? Any insight would be helpful, thanks!
Well isnt it still a poison? So isnt the trip just you being affected by the poison? I dont rember lol
Psilocybin is metabolized into psilocin in the body, a 5-HT agonist, it binds to the receptors in the brain that would normally be used by the neurotransmitter serotonin. The serotonin system is one of four modulatory networks. Serotonin is responsible for such things as sleep/wake cycle, mood, pain control. It may also cause an increase in dopamine, another important neurotransmitter. Of course this description is grossly over simplified and the exact mechanism of action of hallucinogenic drugs is not very well understood.
For more information:
http://thedea.org/yourbrain.html
http://en.wikipedia.org/wiki/Psilocybin
http://www.biopsychiatry.com/psilocybin.htm
its your brain having an orgasim
In our brains there are 5-ht receptors that psilocin binds to . 5-ht is serotonin, so normally serotonin binds at 5-ht receptors. Exactly how shrooms work is not fully understood, but I do know psilocin (A metabolite of the psilocybin found in shrooms.) is a postsynaptic ( The receiving end of a synapse.) 5-ht2A receptor ( A type of 5-ht receptor.) agonist, ( A substance that binds to a receptor and triggers a response in the cell ( In this case a neuron.)) which means psilocin binds to the receiving end of a synapse ( The connection between 2 neurons in this case.) at the 5-ht2A receptors, then triggers a response in the neurons which in turn causes widespread neuronal excitation.
My explaination is also oversimplified.
Edit: Causes should be triggers and then should be which.Quote:
then triggers a response in the neurons which in turn causes widespread neuronal excitation
Great, oversimplified or no, thats exactly what I was looking for thanks guys!