New Marijuana study concerning cancer

A Population-Based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma � Cancer Prevention Research

Just a little piece of info for those who are interested.:thumbsup:

A Population-Based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma

1. Caihua Liang1,
2. Michael D. McClean3,
3. Carmen Marsit2,
4. Brock Christensen1,2,
5. Edward Peters4,
6. Heather H. Nelson5 and
7. Karl T. Kelsey1,2

+ Author Affiliations

1.
Authors' Affiliations: Departments of 1Community Health and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; 3Department of Environmental Health, School of Public Health, Boston University, Boston, Massachusetts; 4Louisiana State University Heath Sciences Center, School of Public Health, New Orleans, Louisiana; and 5Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota

1. Requests for reprints:
Karl T. Kelsey, Department of Community Health, Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI. Phone: 401-863-6420; Fax: 401-863-9008; E-mail: [email protected].

Abstract

Cannabinoids, constituents of marijuana smoke, have been recognized to have potential antitumor properties. However, the epidemiologic evidence addressing the relationship between marijuana use and the induction of head and neck squamous cell carcinoma (HNSCC) is inconsistent and conflicting.

Cases (n = 434) were patients with incident HNSCC disease from nine medical facilities in the Greater Boston, MA area between December 1999 and December 2003. Controls (n = 547) were frequency matched to cases on age (±3 years), gender, and town of residence, randomly selected from Massachusetts town books. A questionnaire was adopted to collect information on lifetime marijuana use (decade-specific exposures) and associations evaluated using unconditional logistic regression.

After adjusting for potential confounders (including smoking and alcohol drinking), 10 to 20 years of marijuana use was associated with a significantly reduced risk of HNSCC [odds ratio (OR)10-<20 years versus never users, 0.38; 95% confidence interval (CI), 0.22-0.67]. Among marijuana users moderate weekly use was associated with reduced risk (OR0.5-<1.5 times versus <0.5 time, 0.52; 95% CI, 0.32-0.85). The magnitude of reduced risk was more pronounced for those who started use at an older age (OR15-<20 years versus never users, 0.53; 95% CI, 0.30-0.95; OR≥20 years versus never users, 0.39; 95% CI, 0.17-0.90; Ptrend < 0.001). These inverse associations did not depend on human papillomavirus 16 antibody status. However, for the subjects who have the same level of smoking or alcohol drinking, we observed attenuated risk of HNSCC among those who use marijuana compared with those who do not.

Our study suggests that moderate marijuana use is associated with reduced risk of HNSCC

Cool beans! :thumbsup:

I just hate them darn Head and Neck Squamous Cell Carcinomas. Had one removed from my forehead a few months ago.

This is a great article concerning methodology of cannabinoids on cancer cells:

Breakthrough Discovered in Medical Marijuana Cancer Treatment