Trying my alcohol talk again
First off, moderator I am a Chemistry graduate from UNC Wilmington with a concentration in Biochemistry, along with minors in Physics and Mathematics. I plan on attending UNC Medical School beginning fall of 2010 after I get some experience under my belt in the medical field by working at the local hospital under the oncology department. I also did some research on THC solubilities for my senior project since it was focused on organic reactions. This being said, don't play this off as some little stoner that doesn't know what in the world they are talking about.
Extension on logical reasoning:
THC will react more readily with alcohol than fat until the temperature of the alcohol approaches the evaporation point of the specific alcohol, which is respectively greater than human blood temperature which is carrying the alcohol to the fatty tissues. (It takes much longer for fat to break down THC and bond with it, which is why people enjoy smoking THC so the high lasts longer)
Though your blood alcohol content may be low, this is actually insufficient information in concluding how much alcohol actually gets to your fatty tissue. It is dependent on many variables... blood pressure, kidney function, liver function, heart rate, etc. It has been estimated that alcohol will effect up to 75% of human organs and tissue before the liver can fully "cleanse" the blood, though there is no real way to test this as it relies on so many variables.
The "hole" that you might be able to place of does not come in chemical reactions, but in the fact that alcohol doesn't absorb into fatty cells. It does however, run through the bloodstream that runs through fatty tissue, and thus theoretically should be able to react with some of the THC in the cells. The reply to my previous thread that alcohol and THC will have organic reactions based on organic acids is true, but allows for numerous reactions and synthesis based on the chemical formation of both alcohols and THC. This allows numerous possible organic reactions as the alcohol passes through the blood stream and along the fatty cells.
This is where I am asking for opinions. It has nothing to do with the organic solubility as it has already been proven that THC is more soluble in alcohol than in fats at lower temperatures (low in this case being chemically or <100 F) or the BAC seeing that even if you only consumed a cup of alcohol, which isn't difficult with many liquors, you are still passing 3/4 of a cup of alcohol through your tissue (if the 75% approximation is correct). Which is enough to pull tons of THC, not all, from your cells.
I am looking more for biological holes than chemical, though if you have good reasoning I would be happy to hear it. Biological downfalls like possible enzyme problems, better liver function approximations, blood flow misdirection, etc. would be far greater and allowing me to move on from this theory than... no the BAC is too low or no it is organically soluble and bonds at numerous points in THC... which I know. I am not talking about changing the THC in the body, I am talking about removing it through the liver, kidneys, and bladder along with the alcohol it bonds to.
I am always happy to admit when I am wrong when someone proves it wrong, but to throw out elementary chemistry and then lock the thread because you assume that you know more being a weed forum operator (I don't know your educational background so who knows) is a little strange. Didn't even give me time to respond to my last post before you shut it down.
Trying my alcohol talk again
The problem I see is that thc is not soluble in standard alcohol. Say 80 proof. It takes a higher prrof alcohol to mix with thc. Try picking up or making some honey oil and you'll see what I mean. It won't mix. But if you step up to say Everclear at 180 proof it'll mix. So in order to have alcohol effect your ths levels in your fat cells you'd need use higher proof alcohol. And then the higher proof you go it evaporates at lower temps, so it probably wouldn't work either.
Trying my alcohol talk again
First of all waddle, there was no need for the since it was closed so abruptly comment so I removed it from the title. Try something like that again and see what happens. I can't quite tell if you're trying to get an attitude with me or not but if you are it won't last for long.
Next, in addition to not offering any proof the thread was turning into a thread about how much alcohol everyone consumes.
Now if you want to go do some research, you need to get some books or reference materials on the pharmaceutics of alcohol in the body. Trust me many have came before you and already done the research on the absorbtion, distribution, and elimination of alcohol in the body. Are you familiar with first and second order kinetics? You might be able to use some online services at the hospital like Medline.
Once you get some information on the pharmaceutics and pharmacology of alcohol then try to apply some of your chemistry degree into incorporating the two. Until then this just seems pointless because it looks like a bunch of speculation and no facts or evidence.
Quote:
Originally Posted by waddlecaudle
I am always happy to admit when I am wrong when someone proves it wrong, but to throw out elementary chemistry and then lock the thread because you assume that you know more being a weed forum operator (I don't know your educational background so who knows) is a little strange. Didn't even give me time to respond to my last post before you shut it down.
First of all, I'm pretty sure I waited some time before closing the thread. Second, as a chemistry major and thus a scientist, you should know that the basis of scientific method is to form a hypothesis and then test it to prove it is right, not to come up with a hypothesis and have others prove it wrong. Congrats on the degree but you've got a ways to catch up to me in the medical degree field and I'm not just some weed forum operator.
Quote:
Originally Posted by waddlecaudle
(It takes much longer for fat to break down THC and bond with it, which is why people enjoy smoking THC so the high lasts longer)
Lasts longer than what, what are you comparing it to?
Here's a question for ya, where exactly are the THC metabolites stored, intracellular or extracellular? What's the plasma binding percentage of THC and THC metabolites?
From everything I know about THC metabolism, the problem doesn't lie in the fatty tissue but the rate limiting step is in the kidneys and liver. Fat solubility is important but not as important as that at high saturation levels the kidneys and liver can't remove the metabolites fast enough.
Trying my alcohol talk again
fakeboobs, i'll walk the straight and narrow. i swear ;)
Trying my alcohol talk again
Quote:
Originally Posted by FakeBoobsRule
Until then this just seems pointless because it looks like a bunch of speculation and no facts or evidence.
Direct knowledge of pure fact is not possible.
according to Weber. hah.
