French Tolerance Study 2/09

Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain.
Boucher AA, Vivier L, Metna-Laurent M, Brayda-Bruno L, Mons N, Arnold JC, Micheau J.

CNIC, Université de Bordeaux, CNRS UMR, Talence, France.

Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One group of animals was not pretreated with THC, whereas another group was injected with 13 daily injections of THC before memory testing in the Morris water maze. Both groups were administered with THC throughout the memory-testing phase of the experiment. THC decreased spatial memory and reversal learning, even in animals that received the THC pretreatment and were tolerant to the locomotor suppressant effects of the drug. Zif268 immunoreactivity was reduced in the CA3 of the hippocampus and in the prefrontal cortex only in non-pretreated animals, indicating that although tolerance to the effects of THC on neuronal activity was evident, cannabinoid-induced memory impairment in these animals persisted even after 24 days of exposure. This study shows that after extended administration of THC, its spatial memory-impairing effects are resistant to tolerance.

Behav Pharmacol. 2009 Feb;20(1):45-55.

O.K.! :stoned::stoned: :jointsmile: PR

I can dig that, the last mouse I talked to, couldn't remember where he hid his cheese ... dumbass stoner mouse :jointsmile:

That's a nice study.

Basically the more you smoke, the more resistant you become to forgetting stuff. Makes sense.

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Originally Posted by thcbongman

Basically the more you smoke, the more resistant you become to forgetting stuff.

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I didnt understand this way... i did understand that the more you smoke the more resistent to the THC effects you get (tolerance), but the memory impairing effects remains the same, regardless the level of tolerance. So we keep forgetting, no matter how tolerant to THC we are.

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Originally Posted by beachguy in thongs

THC decreased spatial memory and reversal learning, even in animals that (...) were tolerant to the (...) effects of the drug.

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Originally Posted by beachguy in thongs

This study shows that after extended administration of THC, its (THC´s) spatial memory-impairing effects are resistant to tolerance.

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My personal experience tends to confirm it... i have a reasonably high tolerance, in fact my highs last much less than they used to, and are also far less intense, and yet my memory remains almost as bad as it became after i started to smoke... :jointsmile:

Did someone mention cheese....I love cheese.

I think it's great that the French did a study on the effects cheese has on memory.......:wtf:

It mentions that the cheese will still knock you on your butt, no matter how long you smoke it. :rastasmoke:

I'm curious as to whether or not these effects are persistent after a long period of abstinence, and whether or not they are actually present in humans.

Have any reliable studies been done on the effects on memory in humans that someone could refer me to?

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Originally Posted by jsdinosaur

Have any reliable studies been done on the effects on memory in humans that someone could refer me to?

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I think i did read something about this... somewhere... but i cant remember where... :D

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Originally Posted by Coelho

I didnt understand this way... i did understand that the more you smoke the more resistent to the THC effects you get (tolerance), but the memory impairing effects remains the same, regardless the level of tolerance. So we keep forgetting, no matter how tolerant to THC we are.





My personal experience tends to confirm it... i have a reasonably high tolerance, in fact my highs last much less than they used to, and are also far less intense, and yet my memory remains almost as bad as it became after i started to smoke... :jointsmile:

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But if you were more resistant of the effects of THC, wouldn't you also become more resistant to the impairing effects on memory as well? Like when you first smoke, you feel more burnt-out, but as you smoke more, you feel the effects of the burnout less. Why wouldn't it be the same with memory impairment.

I mean I feel like I have a good memory overall and that cannabis hasn't impaired it, only in the short-term when high.