urine temperature too hot?

Hey I'm new to the boards but I have a question that I can't seem to find the answer to anywhere. I know that when testing urine (just for reference we're talking substitution here), it has to be within a certain temperature range. BUT, how high can normal urine be heated without any adverse side effects?

For example, if I have a heater pad attached to a bottle of substituted urine, and that urine gets up to 100, 110, 120, etc degrees and I've already practiced a cooling time to get back to the correct temperature, did the urine being at 110-120 degrees affect it as a valid testing sample? Is there a maximum temp where it does affect it?

Thanks.