Is there anyway

Is there any way that the thc receptors in my brain can get blocked? I buy my stuff from medical co ops here in so cali but i cant for the life of me seem to get high. i seriously think im being ripped off if i buy 75 dollar meds and dont even get a 10 minute buzz. has anyone ever not been able to get high for a long period of time?? i know people say the first time you smoke you wont get high why is that? all input would be greatly appreciated.

You'd have to take a CB receptor antagonist. Maybe, because of opioid use, or, some other phenomena, your CB1 receptors have depleted.

Even if you took a CB receptor agonist, it would not "deplete" your receptors. All receptors clear relatively quickly (with some exceptions). Anyway, try cooking with it if smoking won't get ya high.