Here, you want some serious shit???

[beachguy in thongs]

Fuck off.

11,000 meaningful posts.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16318877&query_hl=1
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=full_report&list_uids=9290
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604107
http://www.ebi.uniprot.org/entry/Q9Y2T6

GPR55 found to be a CB receptor.
Here's some freakin' information. :cursing:

edit: LOL, 12.

[BobBong]

Jeeez... don't get your panties in a twist over people accusing you of spamming 11,000+ posts.... opinions are like assholes, everyone has one and they all stink.

Interesting info though...

Few of the links seem to be outdated though (99-00).. how is this new information?

Bob.

[beachguy in thongs]

Increasing evidence suggests that some cannabinoids mediate their effects independently of the known cannabinoid CB(1) and CB(2) receptors. Two recently published patents indicate that several cannabinoid receptor ligands also bind to the orphan G-protein-coupled receptor GPR55. This receptor is reported to be expressed in several tissues and might function in lipid or vascular biology. Thus, GPR55 might represent a new cannabinoid receptor.

[beachguy in thongs]

...this statement.


Recently, cannabinoid receptor agonists have been reported to impair prepulse inhibition (PPI) of the startle reflex. In the current study, we examined the effect of Delta(9)-tetrahydrocannabinol (THC), the principal psychoactive component of cannabis, on the PPI, and found that THC (10 mg/kg, i.p.) impaired the PPI concomitant with a decrease in the startle response. Antipsychotics such as haloperidol (0.3 mg/kg, i.p.) and risperidone (0.1 mg/kg, i.p.), which are potent dopamine D(2) receptor antagonists, and SR141716 (10 mg/kg, i.p.), a CB(1) cannabinoid receptor antagonist, reversed these THC-induced PPI deficits. Moreover, THC (10 mg/kg) increased dopamine (DA) release in the nucleus accumbens but not medial prefrontal cortex over a 50-100-min period (time of PPI test) after treatment, and SR141716 (10 mg/kg) reversed this increase in DA release induced by THC. These results suggest that dopaminergic hyperfunction in the nucleus accumbens may be involved in THC-induced PPI deficits.

[beachguy in thongs]

It's a reflex we have when we're babies, not exactly sure what prepulse inhibition is. I figure that it's, kind of like, instincts.

[Skink]

Don't get serious on us now,Really... Cannabinoid shannabinoid,just smoke it and relax...LOLz...

[beachguy in thongs]

Don't get serious on us now,Really... Cannabinoid shannabinoid,just smoke it and relax...LOLz...

I can't help it. Once these cannabioid receptors start, they don't stop.

[Skink]

I can't help it. Once these cannabioid receptors start, they don't stop.
Yeah,,,I know that can happen,just eat a popsicle and it shud go away...

[beachguy in thongs]

The two-stick ones or the one-stick? Does it matter what flavor? Or, if it's made out of water?

They found, in 2003, that "Dopamine D1 Rather than D2 Receptor Agonists Disrupt Prepulse Inhibition of Startle in Mice" http://www.nature.com/npp/journal/v28/n1/abs/1300017a.html .

[Skink]

I prefur the one stick red white and blue rocket,but the 2 stick orange is good too,I really can't decide now...

Yes it is sugar and water with artificial colors and flavors... it is good with a glass of ice water on a Hazy,hot day and will boost your awareness of a sad childhood,ah Cannabinoid receptors now have a job to do,thus ending an intellectual preponderance...