Cannabis and MS

[AlmostGone]

Hey guys,

I just ran across this forum tonight and thought I'd check it out. I got a dx of MS about 6 years ago. I'm still on my feet (most of the time) so I can't complain too much. I use about 12mg of Zanaflex daily for muscle spasticity, but it just literally knocks me out. Way back, smoking was recreational, but when the kids came along, .... It's been a long time.

Anyone know of medicinal benefits as far as MS?

[Storm Crow]

Cannabis May Halt Progression Of Multiple Sclerosis
Cannabis May Halt Progression Of Multiple Sclerosis, Study Says - NORML (http://norml.org/index.cfm?Group_ID=7704)

Cannabinoid control of neuroinflammation related to multiple sclerosis
Cannabinoid control of neuroinflammation related to multiple sclerosis (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2190016&tool=pmcentrez)

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2228254&tool=pmcentrez)

Cannabinoid control of neuroinflammation related to multiple sclerosis.
Cannabinoid control of neuroinflammation related to multiple sclerosis. (http://marijuana.researchtoday.net/archive/4/10/1400.htm)

Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite
ScienceDirect - Brain Research : Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-4J84SWW-4&_user=10&_coverDate=03%2F03%2F2006&_alid=654077552&_rdoc=310&_fmt=summary&_orig=search&_cdi=4841&_st=13&_docanchor=&view=c&_ct=1476&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a6b6867275584db6efe473322a24e5bf)

The use of cannabinoids in MS: is it evidence based?
http://www.ukcia.org/research/UseOfCannabinoidsInMSEvidenceBased.pdf

Therapeutic Aspects of Cannabis and Cannabinoids
ROBSON: Br J Psychiatry, Volume 178().February 2001.107-115 (http://www.ukcia.org/research/Thereputic/Therapeut.htm)

Whether whole plant Cannabis extracts can improve intractable neurogenic symptoms?
http://www.ukcia.org/research/WholePlantExtractsImproveNeurogenicSymptoms.pdf

Emerging properties of Cannabinoid medicines in the management of MS
http://www.ukcia.org/research/ManagementOfMultipleSclerosis.pdf

Cannabis use in Spanish patients with multiple sclerosis
Cannabis use in Spanish patients with multiple scl...[J Neurol Sci. 2008] - PubMed Result (http://www.ncbi.nlm.nih.gov/pubmed/18691726?ordinalpos=63&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)


Those are the 10 newest studies that I have collected- if you want more, click the link in my sig! MS is one of the most studied of ailments among cannabis researchers. You might want to also read up on Russo's "Endocannabinoid deficiency theory"-

Clinical Endocannabinoid Deficiency
http://www.freedomtoexhale.com/clinical.pdf

The endocannabinoid system is dysregulated in multiple sclerosis
The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis -- Centonze et al., 10.1093/brain/awm160 -- Brain (http://brain.oxfordjournals.org/cgi/content/abstract/awm160v1)

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis -- Pryce et al. 126 (10): 2191 -- Brain (http://brain.oxfordjournals.org/cgi/content/full/126/10/2191)


There is a LOT more to cannabis than just "getting high"!

Granny :hippy:

[AlmostGone]

I've found most of the scientific evidence over the years. I was really wondering if anyone here might actually deal with MS and what their experience was using reefer to deal with some of the symptoms over an extended period. Something like, "This is where it might help you, and this is where it probably won't". I'm not looking for just an attitude adjustment.

Thanks for the info.