Invention: Morphine-cannabis super-painkiller

[epilepticme]

Has anyone seen anything along these lines before?



Invention: Morphine-cannabis super-painkiller



12:00 11 August 2008
NewScientist.com news service
Justin Mullins


Morphine-cannabis super-painkiller
Pain can often be better managed when two types of painkiller are used together. For example, it has recently become known that cannabinoids such as THC (http://www.newscientist.com/article/mg15921531.100-easing-the-agony.html), the psychoactive ingredient in cannabis, enhance the painkilling effects of opioids such as morphine.
Teaming them up could allow doses to become smaller, reducing the possibility of addiction. But a simple mixture of the drugs produces unpredictable results because the body absorbs them at different rates.
A possible solution is to join together THC and morphine to create a hybrid molecule that is snipped apart by the body, say Joseph Holtman and Peter Crooks at the University of Kentucky College of Medicine (http://www.mc.uky.edu/medicine/) in Lexington, Kentucky.
Their idea is to bind the two drugs together using a linking molecule such as an ester (http://en.wikipedia.org/wiki/Ester). When the body snips this linking group, both drugs are released at the site where they are needed. That should ensure both drugs will be absorbed at the same rate, making it easier to work out doses for patients.
Read the full morphine-cannabis supermolecule (http://www.wipo.int/pctdb/en/wo.jsp?WO=2008045556) painkiller patent application.

[veggii]

there just know figuring that out wow they are slow been doing that for years.....when you get that kinda of extreme pain it will make you crazy if you dont get some relief.....

:hippy: :hippy: :hippy:

[Storm Crow]

Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.
Clinical Studies and Case Reports (http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=178)

Cannabinoids, in combination with (NSAIDS), produce a synergistic analgesic effect
Community Forum - View Single Post - Cannabinoids Enhance Analgesic Effects Of Anti-Inflammatory Drugs (http://www.medjournal.com/forum/showpost.php?p=1587&postcount=1)

Add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain -
Clinical Studies and Case Reports (http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=197)

The analgesic properties of delta-9-tetrahydrocannabinol and codeine.
Clinical Studies and Case Reports (http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=17)


and it doesn't do too bad on it's own, either!- Granny:hippy:

[SouthernGuerilla]

Has anyone seen anything along these lines before?



Invention: Morphine-cannabis super-painkiller



12:00 11 August 2008
NewScientist.com news service
Justin Mullins


Morphine-cannabis super-painkiller
Pain can often be better managed when two types of painkiller are used together. For example, it has recently become known that cannabinoids such as THC (http://www.newscientist.com/article/mg15921531.100-easing-the-agony.html), the psychoactive ingredient in cannabis, enhance the painkilling effects of opioids such as morphine.
Teaming them up could allow doses to become smaller, reducing the possibility of addiction. But a simple mixture of the drugs produces unpredictable results because the body absorbs them at different rates.
A possible solution is to join together THC and morphine to create a hybrid molecule that is snipped apart by the body, say Joseph Holtman and Peter Crooks at the University of Kentucky College of Medicine (http://www.mc.uky.edu/medicine/) in Lexington, Kentucky.
Their idea is to bind the two drugs together using a linking molecule such as an ester (http://en.wikipedia.org/wiki/Ester). When the body snips this linking group, both drugs are released at the site where they are needed. That should ensure both drugs will be absorbed at the same rate, making it easier to work out doses for patients.
Read the full morphine-cannabis supermolecule (http://www.wipo.int/pctdb/en/wo.jsp?WO=2008045556) painkiller patent application.

Very interesting, I'll have to print this up for my mom when I get home. She's taking 60mg of ms cotin several times of day and hates being physically addicted to the morphine. :(

She also doesn't like to smoke pot saying it gives her irregular heartbeats, so she says. Maybe some edibles would be good for her to try?

[NoDrugs4Me]

maybe she's smoking stuff that's too potent or not good quality... ?

edibles can make me flip out... and i SMOKE!

it may affect her differently, though. what's it hurt to offer a brownie, or better yet, Green Dragon! search the forums for that one!

[texas grass]

the last thing that needs to be done is genetically modifying this stuff. keep it in its natural state. there have been too many instances where gm any substance for that gets put in to the human body or back into nature will contaminate everything. and another thing is if they start to modify them they can legally patent the items which is bs.

[trancefusion5]

Teaming them up could allow doses to become smaller, reducing the possibility of addiction.
I guess by taking less you may not gain as much of an addiction, that will be easier to kick but would that really lower the possibility of becoming addicted?
Good post! And I defiantly believe that it can help with the withdrawal symptoms from detox of certain pain relief medications as well.
I love this plant! :D

[Storm Crow]

Before prohibition, cannabis extracts were frequently used in the process of weaning opiate-addicted people off of their drugs. Very little modern research has gone into this formerly common practice, which is a shame. There are a few studies about using cannabis as a substitute for alcohol (in the link below), and addiction is addiction, so Mom might find them interesting.

If you try edibles, start off slow! Panic attacks can occur when a novice gets too large of a dose! I'm a medical user, and the doses that are "normal" for me to eat, would have her flying! So I'm not going to make any "how much" recommendations. But be sure to check out stinkyattic's cannabutter article, lots of good info there. Or do a search on Green Dragon.

Just start her on a small dose, and remember, it is not unusual for there to be a 2 to 3 hour lag between eating and feeling it!

Granny:hippy:

[SouthernGuerilla]

Before prohibition, cannabis extracts were frequently used in the process of weaning opiate-addicted people off of their drugs. Very little modern research has gone into this formerly common practice, which is a shame. There are a few studies about using cannabis as a substitute for alcohol (in the link below), and addiction is addiction, so Mom might find them interesting.

If you try edibles, start off slow! Panic attacks can occur when a novice gets too large of a dose! I'm a medical user, and the doses that are "normal" for me to eat, would have her flying! So I'm not going to make any "how much" recommendations. But be sure to check out stinkyattic's cannabutter article, lots of good info there. Or do a search on Green Dragon.

Just start her on a small dose, and remember, it is not unusual for there to be a 2 to 3 hour lag between eating and feeling it!

Granny:hippy:

Thanks Granny. :rastabanna:

[painretreat]

This is very interesting. I know the pain drives me nuts! Even with the control I have, I am limited as time passes.

Initially, for almost 20 years, I was pretty much strict with my Dr. drug routine, sugery, procedures--etc! I got some Kush and was able to get off opiates. But, it took too much kush and money. so, I do mix them and use small amounts of both, with trepidation.

SG: And for the Mom out there-it is medicine and you need what you need! If she has smoked to being stoned, I could understand her reluctance--use for need is best for me. So, I do a little opiate with a little pot and am getting by. Will have to have a few surgeries soon, like it or not.

I believe if these were options when I was first injured, I would have been able to work many more years without the failed surgeries I had. So, these drug combinations sound promising.

I FEAR PATENTS, as mentioned. A center in Utah has the patent on genetic testing for breast cancer and it costs thousands to get it, so most insurance co's refuse payment for it. If that occurs with this, I'd be up a creek.

The combination of both is not recommended and takes a lot of patience to take such low dose's until you are where you need to be. It would be nice to have science take that risk out, without screwing it up. Fortunately, I increased as slow on pot as I decreased on opiates and it worked. So, I have a more effective combination of treatment without the big expense of mmj alone--until I get my first good grow!!! Then, bye bye opiates! Do the scientist's know the difference of which works best for which pain, I wonder! They haven't figured it out with pain med yet. Like antibiotics, pain pills should be classified as best for what they are best at doing. I find Vicodin works a lot better for bad dental pain than morphine! Like tetracycline is better for acne than pneumonia. Our scientist's just need to study pain more! Until it has something to do with getting a rover on the Mars, we will wait! Frustratingly!

Actually, I am not sure mixing them for one pill is such a good idea. It is nice to use the pot for 'break through' pain and get immediate relief! I think for pain use, we do need to feel our pain at times--just not all the time. pr;):thumbsup::thumbsup: